Key result
Unilateral renal artery plication produced sustained hypertension for ≥27 days in 85.7% of dogs, suggesting the renin-angiotensin system is not critically involved in its maintenance.
Why the study?
Is the renin-angiotensin system critically involved in the maintenance of chronic two-kidney renovascular hypertension in dogs?
Population
Dogs with unilateral renal artery plication (chronic two-kidney hypertension model), n=7 studied chronically.
Comparison
Unilateral renal artery plication reducing renal… vs Sham operation (for sodium retention comparison).
Design
Preclinical
Follow-up
Up to 2 months
Authors
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Questions RAS role in sustaining canine renovascular hypertension; leaves open human translation and need for confirmatory studies.
Is the renin-angiotensin system critically involved in the maintenance of chronic two-kidney renovascular hypertension in dogs?
The renin-angiotensin system is not critically involved in the maintenance of chronic two-kidney renovascular hypertension in dogs.
Be et al. (1976) studied chronic two-kidney hypertension (n=7). Unilateral renal artery plication vs. sham operation was evaluated on sustained elevation in arterial pressure for 27 days or longer. Unilateral renal artery plication produced sustained hypertension for ≥27 days in 85.7% of dogs, suggesting the renin-angiotensin system is not critically involved in its maintenance.
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