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March 1, 1977Circulation ResearchOpen Access

Intrarenal renin-angiotensin-sodium interdependent mechanism controlling postclamp renal artery pressure and renin release in the conscious dog with chronic one-kidney Goldblatt hypertension.

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Why the study?

Does intrarenal blockade of angiotensin II affect postclamp renal artery pressure and renin release in conscious dogs with one-kidney Goldblatt hypertension under varying sodium intake?

Population

8 conscious dogs with one-kidney Goldblatt hypertension

Comparison

Intrarenal blockade of angiotensin II with… vs Responses compared across different time points…

Design

Preclinical

Follow-up

Up to 24 days post-constriction

Authors

CAC R AyersUniversity of VirginiaRKRichard E. KatholiPrairie Education and Research CooperativeEVE D VaughanCornell University

Discussion

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Implication

Supports time- and sodium-dependent angiotensin II role in early canine Goldblatt hypertension; leaves open translation to human renovascular disease.

Key Points

  • This research aims to understand the interdependent mechanisms of renin release and renal artery pressure in chronic one-kidney hypertension.
  • Studied eight conscious dogs with one-kidney Goldblatt hypertension.
  • Interventions included intrarenal blockade of angiotensin II using saralasin acetate during sodium intake variations.
  • Evaluated changes in postclamp renal artery pressure and renin release over time.
  • On normal sodium intake, blockade of angiotensin II decreased postclamp renal artery pressure and increased renin release in the first 5 days after constriction.
  • Postclamp pressure maintenance became less dependent on angiotensin II after 10-14 days, with negligible changes in pressure or renin release upon blockade.
  • A sodium diet of less than 5 mEq/day reinstated the sensitivity of renal pressure and renin release to angiotensin II blockade within 5-10 days.

Structured PICO

Does intrarenal blockade of angiotensin II affect postclamp renal artery pressure and renin release in conscious dogs with one-kidney Goldblatt hypertension under varying sodium intake?

P
Population
8 conscious dogs with one-kidney Goldblatt hypertension
I
Intervention
Intrarenal blockade of angiotensin II with Sar1-Ala8-angiotensin II (saralasin acetate) under normal sodium intake and sodium-restricted diet (<5 mEq/day)
C
Comparator
Responses compared across different time points (first 5 days vs 10-14 days post-constriction) and different sodium diets
O
Outcome
Postclamp renal artery pressure and renin releasesurrogate

The study demonstrates an angiotensin II-sodium interdependent negative feedback mechanism for renin release in a canine model of Goldblatt hypertension.

Cite This Study

Ayers et al. (1977) studied this question.

synapsesocial.com/papers/6a709b035d37378ac1ddba82https://doi.org/10.1161/01.res.40.3.238
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin, Aldosterone, Body Fluid Volumes, and the Baroreceptor Reflex in the Development and Reversal of Goldblatt Hypertension in Conscious Dogs1974 · 140 citations
  2. 2Renal Hemodynamics and Plasma Renin Activity after Renal Artery Constriction in Conscious Dogs1972 · 27 citations
  3. 3Control of Renin Secretion1964 · 265 citations
  4. 4Correlation between Granulation of Juxtaglomerular Cells and Extractable Renin in Rats with Experimental Hypertension.1959 · 90 citations
  5. 5The renin system: Variations in man measured by radioimmunoassay or bioassay1972 · 383 citations