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April 1, 1974Circulation ResearchOpen Access

Renin, Aldosterone, Body Fluid Volumes, and the Baroreceptor Reflex in the Development and Reversal of Goldblatt Hypertension in Conscious Dogs

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Population

Unanesthetized dogs with a sole remaining kidney

Comparison

Renal artery constriction followed by release vs Intact dogs versus sinoaortic…

Design

Preclinical

Follow-up

1 week of constriction, 3 days of release

Authors

JLJean-François LiardMedical College of WisconsinACAllen W. CowleyPreventive CardiologyRMRobert E. McCaaNewYork–Presbyterian Hospital

Discussion

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Member takes

Implication

Renin initiates while volume sustains hypertension after renal artery constriction; extends animal model insights but leaves open human translation.

Structured PICO

P
Population
Unanesthetized dogs with a sole remaining kidney (including intact and sinoaortic baroreceptor-denervated models)
I
Intervention
Renal artery constriction followed by release
C
Comparator
Intact dogs versus sinoaortic baroreceptor-denervated dogs
O
Outcome
Mean arterial blood pressuresurrogate

In a canine model of Goldblatt hypertension, the initial blood pressure rise is driven by renin while the sustained phase is driven by volume expansion, with baroreceptors buffering the acute but not chronic changes.

Cite This Study

Liard et al. (1974) studied this question.

synapsesocial.com/papers/6a75d4c6fbccc8f4fd16261ahttps://doi.org/10.1161/01.res.34.4.549

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect in the Conscious Dog of Constriction of the Renal Artery to a Sole Remaining Kidney on Haemodynamics, Sodium Balance, Body Fluid Volumes, Plasma Renin Concentration and Pressor Responsiveness to Angiotensin1970 · 146 citations
  2. 2Changes in Sodium Balance and Hemodynamics during Development of Experimental Renal Hypertension in Dogs1968 · 22 citations
  3. 3Renin-Angiotensin-Aldosterone System and Sodium Balance in Experimental Renal Hypertension1968 · 57 citations
  4. 4Circulatory and Humoral Changes in the Reversal of Renovascular Hypertension in Sheep by Unclipping the Renal Artery1970 · 19 citations
  5. 5Carotid Sinus Participation in Experimental Renal Hypertension1958 · 54 citations