Why the study?
Does renal artery constriction alter renal hemodynamics and plasma renin activity in conscious dogs?
Population
Conscious dogs
Comparison
Acute and chronic renal artery constriction… vs Baseline (control level before constriction)
Design
Preclinical
Follow-up
At least 2 days
Authors
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Caution against assuming direct hemodynamic control of renin in stenosis models; leaves open mechanisms of transient activation in conscious animals.
Does renal artery constriction alter renal hemodynamics and plasma renin activity in conscious dogs?
Renal artery constriction in conscious dogs induces transient increases in plasma renin activity that do not consistently correlate with changes in renal hemodynamics, challenging previous hypotheses.
Harris et al. (1972) studied this question.
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