Population
Conscious, trained dogs
Comparison
Renal artery constriction and subsequent release vs Baseline/control levels
Design
Preclinical
Follow-up
Up to 5 days of constriction, 48 hours post-release
Authors
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Suggests biphasic renin-to-volume transition in experimental renovascular hypertension; hypothesis-generating and leaves open human translation.
This preclinical study demonstrates that renovascular hypertension involves an initial renin surge followed by volume expansion, and suggests baroreceptor resetting upon restoration of renal perfusion.
Tagawa et al. (1974) studied this question.