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December 1, 1984AJP Regulatory Integrative and Comparative Physiology

Elevated cardiac pressure inhibits renin release after arterial hypotension in conscious dogs

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Why the study?

Does elevated cardiac pressure inhibit renin release after arterial hypotension in conscious dogs?

Population

Conscious dogs with chronically implanted cuffs around the ascending aorta proximal to the brachiocephalic…

Comparison

Inflation of implanted cuffs to cause a… vs Baseline and comparison between different cuff…

Design

Preclinical

Follow-up

1 hour

Authors

MLM. E. LeeTTT. N. ThrasherNational Heart Lung and Blood InstituteDRDiane RamsayNOSM University

Discussion

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Implication

Elevated left atrial pressure may suppress renin release during hypotension in dogs; extends cardiopulmonary-renal reflex models but leaves open human relevance.

Key Points

  • To determine the relative contributions of cardiopulmonary, sinoaortic, and renal baroreceptors in modulating plasma renin activity during controlled reductions in renal perfusion pressure.
  • Conscious dogs were instrumented with chronic cuffs on the ascending aorta (n = 7), suprarenal abdominal aorta (n = 4), or pulmonary artery (n = 4).
  • Cuff inflations were graded to decrease distal arterial and renal perfusion pressure by 0%, 5%, 10%, 20%, or 30% of baseline for 1 hour while left or right atrial pressures and plasma renin activity were monitored.
  • Suprarenal aortic constriction significantly increased plasma renin activity across all tested levels of renal perfusion pressure reduction (P < 0.05) without altering left atrial pressure.
  • Ascending aortic constriction caused equivalent drops in renal perfusion pressure but failed to increase plasma renin activity, coinciding with dose-dependent elevations in left atrial pressure.
  • Pulmonary artery constriction produced systemic hypotension alongside significant increases in both right atrial pressure and plasma renin activity (P < 0.05).

Structured PICO

Does elevated cardiac pressure inhibit renin release after arterial hypotension in conscious dogs?

P
Population
Conscious dogs with chronically implanted cuffs around the ascending aorta proximal to the brachiocephalic artery, the abdominal aorta just proximal to both renal arteries, or the pulmonary artery (n=15).
I
Intervention
Inflation of implanted cuffs to cause a reduction of distal arterial pressure and renal perfusion pressure (RPP) of 0, 5, 10, 20, or 30% of control for 1 hour.
C
Comparator
Baseline (0% reduction) and comparison between different cuff locations (suprarenal vs. ascending aorta vs. pulmonary artery).
O
Outcome
Plasma renin activity (PRA)surrogate

Powerful inhibitory signals arising from the left heart can suppress renin release in response to systemic hypotension.

Cite This Study

Lee et al. (1984) studied this question.

synapsesocial.com/papers/6a855e89734852141cd4ca5ehttps://doi.org/10.1152/ajpregu.1984.247.6.r953
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of inhibition of renin secretion by increased left atrial pressure1985 · 9 citations
  2. 2Atrial natriuretic peptide blocks renin response to renal hypotension1987 · 23 citations
  3. 3Effect of loading right atrial and ventricular receptors on stimulated AVP, ACTH, and renin secretion in awake dogs1995 · 6 citations
  4. 4Arterial baroreceptors control plasma vasopressin responses to graded hypotension in conscious dogs2000 · 23 citations
  5. 5Reflex inhibition of plasma renin activity by increased left ventricular pressure in conscious dogs1989 · 3 citations