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June 1, 1989AJP Regulatory Integrative and Comparative Physiology

Reflex inhibition of plasma renin activity by increased left ventricular pressure in conscious dogs

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Why the study?

Does increased left ventricular pressure reflexively inhibit plasma renin activity in conscious dogs?

Population

Chronically instrumented, conscious dogs (n=12)

Comparison

Intravenous infusions of nitroprusside while… vs Intravenous infusions of nitroprusside (NP) alone

Design

Preclinical

Authors

AGAndrew GormanIdaho National LaboratoryJCJ. S. ChenUniversity of Nebraska Medical Center

Discussion

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Implication

Supports reflex inhibition of PRA by LV pressure in conscious dogs; leaves open translation to clinical settings.

Structured PICO

Does increased left ventricular pressure reflexively inhibit plasma renin activity in conscious dogs?

P
Population
Chronically instrumented, conscious dogs (n=12)
I
Intervention
Intravenous infusions of nitroprusside (NP) while peak systolic LV pressure was elevated by acute ascending aortic occlusion (AAO + NP)
C
Comparator
Intravenous infusions of nitroprusside (NP) alone
O
Outcome
Changes in plasma renin activity (PRA) and heart rate during a 15- to 20-mmHg decrease in arterial blood pressuresurrogate

Increased left ventricular pressure reflexively inhibits the hypotension-induced rise in plasma renin activity via afferent receptors in the LV myocardium.

Cite This Study

Gorman et al. (1989) studied this question.

synapsesocial.com/papers/6a855e89734852141cd4ca5bhttps://doi.org/10.1152/ajpregu.1989.256.6.r1299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated cardiac pressure inhibits renin release after arterial hypotension in conscious dogs1984 · 15 citations
  2. 2Atrial natriuretic peptide blocks renin response to renal hypotension1987 · 23 citations
  3. 3Effect of loading right atrial and ventricular receptors on stimulated AVP, ACTH, and renin secretion in awake dogs1995 · 6 citations
  4. 4Plasma renin activity during exercise in the dog.1976 · 4 citations
  5. 5Chronic effects of a physiological dose of ANP on arterial pressure and renin release1990 · 11 citations