Why the study?
Does infusion of atrial natriuretic peptide inhibit renal hypotension-induced increases in plasma renin activity in conscious dogs?
Population
Conscious dogs with cuffs implanted around the abdominal aorta just above the renal arteries to control…
Comparison
Infusion of 1-28 rat ANP (5 ng X kg-1 X min-1) vs Control
Design
Preclinical
Authors
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ANP suppresses renin response to hypotension in dogs; hypothesis-generating for human volume regulation and requires clinical validation.
Does infusion of atrial natriuretic peptide inhibit renal hypotension-induced increases in plasma renin activity in conscious dogs?
Atrial natriuretic peptide inhibits the renin response to renal hypotension, providing a mechanism for the inhibition of renin during elevated atrial pressure.
Scheuer et al. (1987) studied this question.