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February 1, 2000AJP Regulatory Integrative and Comparative Physiology

Arterial baroreceptors control plasma vasopressin responses to graded hypotension in conscious dogs

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Population

5 conscious dogs prepared with Silastic cuffs on the thoracic inferior vena cava and catheters in the…

Comparison

Graded hypotension under four conditions: 1)… vs Intact (control) condition

Design

Preclinical

Authors

TTT. N. ThrasherNational Heart Lung and Blood InstituteHCHong‐Gen ChenNingbo Product Quality Supervision and Inspection InstituteLKL. C. KeilCreighton University

Discussion

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Implication

Findings in dogs should not inform human baroreflex management; extends evidence distinguishing arterial from cardiac baroreceptor roles in vasopressin regulation.

Structured PICO

P
Population
5 conscious dogs prepared with Silastic cuffs on the thoracic inferior vena cava and catheters in the pericardial space
I
Intervention
Graded hypotension (mean arterial pressure reduced in increments of approximately 10 mmHg) under four conditions: 1) intact, 2) acute cardiac denervation (CD) by intrapericardial infusion of procaine, 3) after sinoaortic denervation (SAD), and 4) during combined SAD+CD
C
Comparator
Intact (control) condition
O
Outcome
Plasma arginine vasopressin (AVP) and plasma renin activity (PRA) responses to graded hypotensionsurrogate

In conscious dogs, the stimulation of arginine vasopressin secretion in response to graded hypotension is primarily driven by unloading arterial baroreceptors rather than cardiac baroreceptors.

Cite This Study

Thrasher et al. (2000) studied this question.

synapsesocial.com/papers/6a855e0f7fcf0fdb395e1b16https://doi.org/10.1152/ajpregu.2000.278.2.r469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relative roles of cardiac and arterial baroreceptors in vasopressin regulation during hemorrhage in conscious dogs.1991 · 40 citations
  2. 2Cardiac and arterial baroreceptor influences in release of vasopressin and renin during hemorrhage1987 · 69 citations
  3. 3Effect of renal denervation on the suppression of renin secretion by vasopressin in conscious dogs1984 · 11 citations
  4. 4Ventricular receptors stimulate vasopressin release during hemorrhage1988 · 52 citations
  5. 5Arterial baroreceptors control blood pressure and vasopressin responses to hemorrhage in conscious dogs1998 · 26 citations