What question did this study set out to answer?

To determine the respective roles of cardiac and sinoaortic baroreceptors in mediating endocrine and drinking responses to acute reductions in cardiac venous return.

September 1, 1990AJP Regulatory Integrative and Comparative Physiology

Effects of baroreceptor denervation on endocrine and drinking responses to caval constriction in dogs

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Population

29 conscious dogs

Comparison

Thoracic inferior vena caval constriction in… vs Sham-denervated dogs undergoing TIVCC

Design

Preclinical

Authors

EQE. W. QuillenUniversity of California, San Francisco LKL. C. KeilCreighton University IRI. A. ReidThe University of Sydney

Discussion

Member takes

Implication

Cardiac baroreceptor pathways selectively mediate AVP release in this canine model; leaves open translation to human volume regulation or HF management.

Key Points

To determine the respective roles of cardiac and sinoaortic baroreceptors in mediating endocrine and drinking responses to acute reductions in cardiac venous return.
Conscious, normally hydrated dogs were allocated to sham-operated (n=9), cardiac-denervated (CD, n=10), sinoaortic-denervated (SAD, n=6), and combined denervated (CD + SAD, n=4) groups.
Hemodynamic, hormonal, and drinking parameters were evaluated during thoracic inferior vena caval constriction (TIVCC) under water-deprived and drinking-permitted conditions.
TIVCC induced comparable decreases in mean arterial pressure (-32 ± 4 mmHg), left atrial pressure (-6.5 ± 1.1 cmH2O), and right atrial pressure (-4.2 ± 0.8 cmH2O) across all groups (P < 0.001).
During water deprivation, AVP rose from 3.6 ± 0.7 to 72.8 ± 12.6 pg/ml in sham dogs (P < 0.001) and 57.1 ± 6.9 pg/ml in SAD dogs, but was blunted to 30.9 ± 3.0 pg/ml in CD and 17.7 ± 4.0 pg/ml in CD + SAD dogs.
Plasma renin activity increased from 4.5 ± 0.7 to 23.8 ± 3.0 ng·ml⁻¹·3 h⁻¹, angiotensin II from 14.0 ± 2.8 to 59.5 ± 13.0 pg/ml (P < 0.001), ACTH from 55 ± 5 to 128 ± 25 pg/ml, and norepinephrine from 298 ± 61 to 654 ± 88 pg/ml similarly in all groups.

Structured PICO

Population

29 conscious dogs (9 sham-denervated, 10 cardiac-denervated [CD], 6 sinoaortic-denervated [SAD], and 4 combined cardiac and sinoaortic-denervated [CD + SAD])

Intervention

Thoracic inferior vena caval constriction (TIVCC) in cardiac, sinoaortic, or combined denervated dogs

Comparator

Sham-denervated dogs undergoing TIVCC

Outcome

Plasma arginine vasopressin (AVP), plasma renin activity (PRA), and water intake (H2OIN)surrogate

Cardiac baroreceptors play a significant role in mediating the arginine vasopressin response to thoracic inferior vena caval constriction in dogs, whereas renin and catecholamine responses appear independent of these specific baroreceptor pathways.

Cite This Study

Quillen et al. (1990) studied this question.

synapsesocial.com/papers/6a855e89734852141cd4ca5a https://doi.org/10.1152/ajpregu.1990.259.3.r618

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Implication

Cardiac baroreceptor pathways selectively mediate AVP release in this canine model; leaves open translation to human volume regulation or HF management.

Effects of baroreceptor denervation on endocrine and drinking responses to caval constriction in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of baroreceptor denervation on endocrine and drinking responses to caval constriction in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider