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February 1, 1984Circulation ResearchOpen Access

Responses of renal hemodynamics and function to acute volume expansion in the conscious dog.

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Why the study?

How does acute volume expansion affect renal hemodynamics and function in conscious dogs with intact versus denervated baroreceptors and vagus nerves?

Population

Conscious dogs with all reflexes intact, sinoaortic arterial baroreceptor denervation, arterial baroreceptor…

Comparison

Acute volume expansion vs Comparison between intact state and various…

Design

Preclinical

Follow-up

10-60 minutes after expansion

Authors

SSSiu Po SitMount Sinai Health SystemHMHironobu MoritaTokai Gakuin UniversitySVStephen F. VatnerHeart Failure & Transplant

Discussion

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Implication

Neural mediation of natriuresis confirmed in dogs; hypothesis-generating for human volume regulation, should not yet change practice.

Structured PICO

How does acute volume expansion affect renal hemodynamics and function in conscious dogs with intact versus denervated baroreceptors and vagus nerves?

P
Population
Conscious dogs with all reflexes intact, sinoaortic arterial baroreceptor denervation, arterial baroreceptor denervation plus bilateral stellectomy, or arterial baroreceptor denervation plus bilateral vagotomy
I
Intervention
Acute volume expansion (isotonic saline infusion or 20% of estimated blood volume with isooncotic, isotonic 3% dextran in saline solution)
C
Comparator
Comparison between intact state and various denervation states (sinoaortic arterial baroreceptor denervation, bilateral stellectomy, bilateral vagotomy)
O
Outcome
Renal hemodynamics (renal blood flow, calculated renal vascular resistance, arterial pressure, heart rate, central venous pressure) and renal function (urine flow rate, sodium excretion)surrogate

This preclinical study demonstrates that vagal pathways play a significant role in mediating the diuretic and natriuretic responses to acute volume expansion in conscious dogs.

Cite This Study

Sit et al. (1984) studied this question.

synapsesocial.com/papers/6a852ee44edd3eca19cf2273https://doi.org/10.1161/01.res.54.2.185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contribution of Intravascular Receptors to the Renal Responses Following Intravascular Volume Expansion1965 · 16 citations
  2. 2Neither dorsal root nor baroreceptor afferents are necessary for eliciting the renal responses to acute intravascular volume expansion in the primate Macaca fascicularis.1979 · 9 citations
  3. 3Reflexes elicited by acute stretch of atrial vs. pulmonary receptors in conscious dogs1982 · 29 citations
  4. 4Cardiopulmonary sympathetic afferent influences on renal nerve activity1977 · 49 citations
  5. 5Cardiovascular Reflexes from Stretch of Pulmonary Vein-Atrial Junctions in the Dog1970 · 57 citations