June 1, 1982AJP Heart and Circulatory Physiology
Effects of left atrial stretch in cardiac-denervated and intact conscious dogs
Why the study?
Does left atrial stretch or volume expansion elicit different cardiovascular and renal responses in cardiac-denervated dogs compared to intact dogs?
Population
Conscious dogs with surgically denervated hearts and sham-operated control dogs
Comparison
1) Inflation of a balloon in the left atrium and… vs Sham-operated control dogs undergoing identical…
Design
Preclinical
Authors
Discussion
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Implication
Atrial stretch diuresis requires intact cardiac nerves in dogs; hypothesis-generating for human cardiorenal reflexes.
Structured PICO
Does left atrial stretch or volume expansion elicit different cardiovascular and renal responses in cardiac-denervated dogs compared to intact dogs?
P
Population
Conscious dogs with surgically denervated hearts and sham-operated control dogs
I
Intervention
1) Inflation of a balloon in the left atrium and 2) intravascular volume expansion (infusion of 6% dextran in isotonic saline, 16% of estimated blood volume)
C
Comparator
Sham-operated control dogs undergoing identical experiments
O
Outcome
Cardiovascular and renal function (left atrial pressure, heart rate, urine flow, sodium excretion, central venous pressure)surrogate
Left atrial stretch-induced diuresis and natriuresis depend on intact cardiac neural pathways, whereas volume expansion-induced responses do not.
Cite This Study
Fater et al. (1982) studied this question.