What question did this study set out to answer?

To investigate the role of the cardiac-renal-neural reflex and renal sympathetic nerve activity in diuresis and natriuresis induced by left atrial balloon distension.

February 1, 1993AJP Regulatory Integrative and Comparative Physiology

Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension

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Why the study?

Does left atrial distension induce natriuresis via a cardiac-renal-neural reflex in conscious dogs?

Population

Conscious female mongrel dogs (n=22)

Comparison

Left atrial balloon inflation (distension) vs Sham-operated vs cardiac-denervated vs…

Design

Preclinical, assigned randomly

Authors

KMKenju MikiNara Women's University YHYoshiaki HayashidaSaga University KSK. ShirakiUniversity of Occupational and Environmental Health Japan

Discussion

Member takes

Implication

Hypothesis-generating for cardiac-renal reflex natriuresis; human relevance and therapeutic translation require prospective study.

Key Points

To investigate the role of the cardiac-renal-neural reflex and renal sympathetic nerve activity in diuresis and natriuresis induced by left atrial balloon distension.
Randomly assigned conscious female mongrel dogs into three groups: sham-operated (n = 8), cardiac-denervated (n = 6), and renal-denervated (n = 8).
Chronically instrumented dogs with bipolar stainless steel wire electrodes to continuously record renal sympathetic nerve activity during left atrial balloon inflation.
In sham-operated dogs, balloon inflation increased left atrial pressure by 7.7 ± 1.7 mmHg, reduced renal sympathetic nerve activity by 66.6 ± 5.5%, and increased sodium excretion by 300 ± 69%, urine flow by 441 ± 142%, and osmolal excretion by 60 ± 12%.
Both cardiac denervation and renal denervation abolished the increases in diuresis and natriuresis during balloon inflation, with renal sympathetic nerve activity showing no significant change in cardiac-denervated dogs.

Structured PICO

Does left atrial distension induce natriuresis via a cardiac-renal-neural reflex in conscious dogs?

Population

Conscious female mongrel dogs (n=22)

Intervention

Left atrial balloon inflation (distension)

Comparator

Sham-operated (n=8) vs cardiac-denervated (n=6) vs renal-denervated (n=8) groups

Outcome

Renal sympathetic nerve activity (RSNA), urine flow, osmolal excretion, and sodium excretionsurrogate

A sustained reduction of renal sympathetic nerve activity originating from left atrial mechanoreceptors plays a major role in the natriuresis during left atrial distension.

Cite This Study

Miki et al. (1993) studied this question.

synapsesocial.com/papers/6a76de6ca7498e5110ae1f1f https://doi.org/10.1152/ajpregu.1993.264.2.r369

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Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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