Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 7, 1981Quarterly Journal of Experimental PhysiologyOpen Access

The Role of Renal Nerves in the Diuresis and Natriuresis Caused by Stimulation of Atrial Receptors

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the renal nerve contribute to diuresis and natriuresis caused by stimulation of atrial receptors in dogs?

Population

Anaesthetized dogs in which one kidney had been surgically denervated

Comparison

Stimulation of left atrial receptors by… vs Intact kidney (within-subject comparison)

Design

Preclinical

Authors

NSNadarajah SreeharanUniversity of JaffnaCKC. T. KappagodaUniversity of California, DavisRLR. J. LindenLeeds General Infirmary

Discussion

Loading...

Member takes

Implication

Renal nerve contribution to atrial natriuresis shown in dogs; leaves open translation to human volume regulation and requires clinical validation.

Key Points

  • To determine the contribution of renal nerves to diuresis and sodium excretion induced by left atrial receptor stimulation.
  • Anaesthetized dogs underwent unilateral surgical renal denervation.
  • Left atrial receptors were stimulated via balloon distension at the pulmonary vein-left atrial junctions or in the body of the left atrium.
  • Diuretic and natriuretic responses were compared between the surgically denervated kidney and the contralateral intact kidney.
  • Diuretic and natriuretic responses occurred in both kidneys following atrial receptor stimulation, but both responses were significantly greater in intact kidneys compared to denervated kidneys.
  • In denervated kidneys, the natriuretic response correlated significantly with increases in heart rate triggered by atrial receptor stimulation.
  • Fluid loss in denervated kidneys was mediated by a humoral pathway, whereas the intact renal nerves accounted for the majority of urine and sodium excretion.

Structured PICO

Does the renal nerve contribute to diuresis and natriuresis caused by stimulation of atrial receptors in dogs?

P
Population
Anaesthetized dogs in which one kidney had been surgically denervated
I
Intervention
Stimulation of left atrial receptors by distending balloons located either at the pulmonary vein-left atrial junctions or in the body of the left atrium
C
Comparator
Intact kidney (within-subject comparison)
O
Outcome
Diuretic and natriuretic responses (urine flow and sodium excretion)surrogate

Renal nerves contribute significantly to the increases in urine flow and sodium excretion in response to stimulation of atrial receptors.

Cite This Study

Sreeharan et al. (1981) studied this question.

synapsesocial.com/papers/6a7a28c302ab7a73dd02c0e8https://doi.org/10.1113/expphysiol.1981.sp002543
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE TIME COURSE OF THE DIURETIC RESPONSE TO LEFT ATRIAL DISTENSION1973 · 14 citations
  2. 2Effect of decreased renal sympathetic nerve activity on renal tubular sodium reabsorption1978 · 71 citations
  3. 3THE EFFECTS OF LEFT ATRIAL DISTENSION UPON URINE FLOW FROM THE ISOLATED PERFUSED KIDNEY1970 · 27 citations
  4. 4The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity1972 · 221 citations
  5. 5The role of left atrial receptors in the diuretic response to left atrial distension1968 · 85 citations