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April 1, 1988The Journal of PhysiologyOpen Access

The effect of stimulation of the atrial receptors on plasma renin activity in the dog.

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Why the study?

Does stimulation of atrial receptors reduce plasma renin activity in dogs?

Population

Dogs anaesthetized with alpha-chloralose

Comparison

Stimulation of left atrial receptors by… vs Control periods without balloon distension

Design

Preclinical

Authors

MDMark J. DrinkhillUniversity of LeedsMHMartin N. HicksAndrews UniversityDMD. A. S. G. MaryUniversity of Pittsburgh

Discussion

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Implication

Supports vagally mediated renin suppression in dogs; leaves open translation to human volume homeostasis or therapy.

Structured PICO

Does stimulation of atrial receptors reduce plasma renin activity in dogs?

P
Population
Dogs anaesthetized with alpha-chloralose
I
Intervention
Stimulation of left atrial receptors by distension of a large balloon in the left atrium or small balloons at the pulmonary vein-atrial junctions and atrial appendage
C
Comparator
Control periods without balloon distension
O
Outcome
Change in plasma renin activitysurrogate

Stimulation of atrial receptors reflexly decreases plasma renin activity via myelinated vagal fibers.

Cite This Study

Drinkhill et al. (1988) studied this question.

synapsesocial.com/papers/6a85467032b8a2b0ded6a85fhttps://doi.org/10.1113/jphysiol.1988.sp017050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE NATURE OF ATRIAL RECEPTORS RESPONSIBLE FOR THE INCREASE IN URINE FLOW CAUSED BY DISTENSION OF THE LEFT ATRIUM IN THE DOG1981 · 11 citations
  2. 2THE EFFECT OF COOLING ON TRANSMISSION OF IMPULSES IN VAGAL NERVE FIBRES ATTACHED TO ATRIAL RECEPTORS IN THE DOG1981 · 20 citations
  3. 3The nature of the atrial receptors responsible for a reflex decrease in activity in renal nerves in the dog1980 · 47 citations
  4. 4Reflex suppression of renin secretion during distention of cardiopulmonary receptors in dogs.1976 · 85 citations
  5. 5The role of left atrial receptors in the diuretic response to left atrial distension1968 · 85 citations