Key result
Left atrial balloon distension reduces coronary blood flow via vagal and sympathetic reflex pathways.
Why the study?
Does stimulation of left atrial receptors affect coronary blood flow in anaesthetized dogs?
Population
7 dogs anaesthetized with alpha-chloralose
Comparison
Stimulation of left atrial receptors by… vs Baseline/absence of balloon distension, and…
Design
Preclinical
Authors
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Hypothesis-generating for atrial receptor-mediated coronary regulation in dogs; leaves open human relevance and precludes practice change.
Does stimulation of left atrial receptors affect coronary blood flow in anaesthetized dogs?
Stimulation of left atrial receptors reflexly decreases coronary blood flow via afferent vagal fibers and efferent cardiac sympathetic pathways.
Drinkhill et al. (1989) studied Anaesthetized dogs (n=7). Stimulation of left atrial receptors via balloon distension was evaluated on Mean coronary blood flow. Stimulation of left atrial receptors by balloon distension resulted in a reflex decrease in mean coronary blood flow involving afferent vagal fibers and efferent cardiac sympathetic pathways.
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