What question did this study set out to answer?

To investigate the reflex mechanisms through which left atrial-pulmonary vein distention alters renal renin secretion.

April 1, 1976Circulation Research

Reflex suppression of renin secretion during distention of cardiopulmonary receptors in dogs.

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Why the study?

Does left atrial-pulmonary vein distention reduce renin secretion in sodium-restricted dogs?

Population

Sodium-restricted dogs anesthetized with chloralose and breathing spontaneously

Comparison

Brief periods of left atrial-pulmonary vein… vs Control and/or denervated kidney

Design

Preclinical

Authors

JZJ. E. ZehrUniversity of Illinois Urbana-Champaign JHJames A. HasbargenFitzsimons Army Medical Center KKK D KurzUniversity of Victoria

Discussion

Member takes

Implication

Identifies vagal-renal reflex control of renin in dogs; hypothesis-generating for human cardiorenal volume regulation.

Key Points

To investigate the reflex mechanisms through which left atrial-pulmonary vein distention alters renal renin secretion.
Assessed chloralose-anesthetized, sodium-restricted dogs across three groups: intact nerves (Series 1, 32 trials in N=7), unilateral renal denervation (Series 2, 58 trials in N=12), and bilateral cervical vagotomy (Series 3, 30 trials in N=6).
Calculated renin secretion using renal arteriovenous differences via radioimmunoassay multiplied by renal plasma flow measured with an electromagnetic flowmeter.
In intact animals, left atrial distention suppressed renin secretion to 56% of control levels without altering arterial pressure, central venous pressure, or renal blood flow.
In unilaterally denervated dogs, distention reduced renin secretion to 58% of control in the innervated kidney but caused no change in the denervated kidney.
In bilaterally vagotomized dogs, atrial distention elicited no detectable change in renin secretion.

Structured PICO

Does left atrial-pulmonary vein distention reduce renin secretion in sodium-restricted dogs?

Population

Sodium-restricted dogs anesthetized with chloralose and breathing spontaneously (n=25 total: 7 with intact renal nerves and vagi, 12 with unilateral renal denervation, 6 with bilateral cervical vagotomy)

Intervention

Brief periods of left atrial-pulmonary vein distention

Comparator

Control (baseline before distention) and/or denervated kidney

Outcome

Rate of renin secretion (calculated as renal venous minus arterial renin activity times renal plasma flow)surrogate

Left atrial distention reflexly reduces renin secretion via vagal afferent and renal sympathetic efferent pathways.

Cite This Study

Zehr et al. (1976) studied this question.

synapsesocial.com/papers/6a72ca5126770c2b8de193aa https://doi.org/10.1161/01.res.38.4.232

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Reflex suppression of renin secretion during distention of cardiopulmonary receptors in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Reflex suppression of renin secretion during distention of cardiopulmonary receptors in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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