April 1, 1981Acta Physiologica Scandinavica

The role of left atrial receptors in the regulation of renin release in anesthetized dogs

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Population

Anesthetized dogs

Comparison

Non-hypotensive arterial hemorrhage with left… vs Non-hypotensive arterial hemorrhage allowing…

Design

Preclinical

Authors

HHHallvard HoldaasUniversity of Copenhagen GDGerald F. DiBonaGeneral Cardiology

Discussion

Member takes

Implication

Animal data on atrial renin control should not change practice; leaves open human translation of this reflex.

Structured PICO

Population

Anesthetized dogs

Intervention

Non-hypotensive arterial hemorrhage with left atrial pressure kept constant via left atrial balloon inflation

Comparator

Non-hypotensive arterial hemorrhage allowing left atrial pressure to decrease

Outcome

Renin releasesurrogate

This study demonstrates that left atrial cardiopulmonary receptors sense changes in blood volume independent of arterial pressure, mediating renin release via a neural reflex arc.

Cite This Study

Holdaas et al. (1981) studied this question.

synapsesocial.com/papers/6a85467032b8a2b0ded6a861 https://doi.org/10.1111/j.1748-1716.1981.tb06769.x

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