What question did this study set out to answer?

To determine whether acute withdrawal of renal sympathetic nerve tone is required to inhibit renin release during elevated left atrial pressure and concurrent hypotension.

February 1, 1989AJP Regulatory Integrative and Comparative Physiology

Role of renal sympathetic nerves in renin inhibition by elevated left atrial pressure

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Why the study?

Does withdrawal of renal sympathetic tone mediate the inhibition of renin response to systemic hypotension by elevated left atrial pressure in conscious dogs?

Population

Conscious dogs

Comparison

Partial constriction of the ascending aorta with… vs Constriction of the abdominal aorta

Design

Preclinical

Authors

DSDeborah A. ScheuerUniversity of Florida TTT. N. ThrasherNational Heart Lung and Blood Institute DRD. J. RamsayCentennial College

Discussion

Member takes

Implication

Renal sympathetic withdrawal is not required for left atrial pressure-mediated renin inhibition; leaves open alternative mechanisms in conscious dogs.

Key Points

To determine whether acute withdrawal of renal sympathetic nerve tone is required to inhibit renin release during elevated left atrial pressure and concurrent hypotension.
Examined conscious dogs subjected to partial ascending aortic constriction to concurrently decrease renal perfusion pressure (RPP) by up to 30% and raise left atrial pressure (LAP).
Reversibly blocked beta-adrenergic sympathetic neural control of renin release using propranolol infusions and compared responses to abdominal aortic constriction.
Renin release showed no increase during ascending aortic constriction both with and without propranolol infusion (P > 0.1), while LAP and atrial natriuretic factor rose normally.
Identical reductions in RPP during abdominal aortic constriction provoked a significant increase in renin release (P < 0.03).

Structured PICO

Does withdrawal of renal sympathetic tone mediate the inhibition of renin response to systemic hypotension by elevated left atrial pressure in conscious dogs?

Population

Conscious dogs

Intervention

Partial constriction of the ascending aorta with or without propranolol infusion

Comparator

Constriction of the abdominal aorta (producing identical reductions in renal perfusion pressure)

Outcome

Renin responsesurrogate

Acute withdrawal of renal sympathetic tone is not necessary for the inhibition of the renin response to systemic hypotension by elevated left atrial pressure.

Cite This Study

Scheuer et al. (1989) studied this question.

synapsesocial.com/papers/6a855e89734852141cd4ca5c https://doi.org/10.1152/ajpregu.1989.256.2.r413

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Implication

Renal sympathetic withdrawal is not required for left atrial pressure-mediated renin inhibition; leaves open alternative mechanisms in conscious dogs.

Role of renal sympathetic nerves in renin inhibition by elevated left atrial pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Role of renal sympathetic nerves in renin inhibition by elevated left atrial pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider