October 1, 1966Circulation ResearchOpen Access

Neural Stimulation of Release of Renin

View Full Paper

Ask AI

Bookmark

Why the study?

Does neural stimulation induce renal release of renin in anesthetized dogs independent of renal perfusion pressure or flow?

Population

Anesthetized dogs (some fed low-sodium diet, some standard kennel diet)

Comparison

Neural stimulation via bleeding, common carotid… vs Ganglion blockade, local anesthesia of renal…

Design

Preclinical

Authors

RBRuben BuñagCleveland Clinic IPIrvine H. PagePennine Acute Hospitals NHS Trust JMJ. W. McCubbinInternational Academy of Business and New Technologies

Discussion

Member takes

Implication

Renal nerve activity may drive renin release without hemodynamic shifts; extends mechanistic models but leaves open human relevance.

Structured PICO

Does neural stimulation induce renal release of renin in anesthetized dogs independent of renal perfusion pressure or flow?

Population

Anesthetized dogs (some fed low-sodium diet, some standard kennel diet)

Intervention

Neural stimulation via bleeding, common carotid artery occlusion, or infusions of norepinephrine, tyramine, or DMPP

Comparator

Ganglion blockade, local anesthesia of renal nerves, or infusions of isoproterenol, angiotensin, vasopressin, serotonin, or acetylcholine

Outcome

Renal release of reninsurrogate

This study demonstrates that neural stimuli can directly cause the release of renin independent of changes in renal perfusion pressure or blood flow.

Cite This Study

Buñag et al. (1966) studied this question.

synapsesocial.com/papers/6a20f55b34bef10fdaeb2d6f https://doi.org/10.1161/01.res.19.4.851

View Full Paper

Ask AI

Bookmark

October 1, 1966Circulation ResearchOpen Access

Neural Stimulation of Release of Renin

View Full Paper

Ask AI

Bookmark

Why the study?

Does neural stimulation induce renal release of renin in anesthetized dogs independent of renal perfusion pressure or flow?

Population

Anesthetized dogs (some fed low-sodium diet, some standard kennel diet)

Comparison

Neural stimulation via bleeding, common carotid… vs Ganglion blockade, local anesthesia of renal…

Design

Preclinical

Authors

RBRuben BuñagCleveland Clinic IPIrvine H. PagePennine Acute Hospitals NHS Trust JMJ. W. McCubbinInternational Academy of Business and New Technologies

Discussion

Member takes

Implication

Renal nerve activity may drive renin release without hemodynamic shifts; extends mechanistic models but leaves open human relevance.

Structured PICO

Does neural stimulation induce renal release of renin in anesthetized dogs independent of renal perfusion pressure or flow?

Population

Anesthetized dogs (some fed low-sodium diet, some standard kennel diet)

Intervention

Neural stimulation via bleeding, common carotid artery occlusion, or infusions of norepinephrine, tyramine, or DMPP

Comparator

Ganglion blockade, local anesthesia of renal nerves, or infusions of isoproterenol, angiotensin, vasopressin, serotonin, or acetylcholine

Outcome

Renal release of reninsurrogate

This study demonstrates that neural stimuli can directly cause the release of renin independent of changes in renal perfusion pressure or blood flow.

Cite This Study

Buñag et al. (1966) studied this question.

synapsesocial.com/papers/6a20f55b34bef10fdaeb2d6f https://doi.org/10.1161/01.res.19.4.851

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark