What question did this study set out to answer?

To elucidate whether renal nerves are necessary for promoting renal sodium retention during progressive, chronic reductions in cardiac output.

September 1, 1995AJP Regulatory Integrative and Comparative Physiology

Influence of the renal nerves on sodium excretion during progressive reductions in cardiac output

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Why the study?

Does renal denervation affect sodium excretion during progressive reductions in cardiac output in a dog model?

Population

5 dogs with surgically divided urinary bladders to allow separate 24-h urine collection from innervated and…

Comparison

Progressive reductions in cardiac output via… vs Innervated vs denervated kidneys within the same…

Design

Preclinical

Follow-up

9 days of progressive constriction followed by release

Authors

TLThomas E. LohmeierJackson Memorial Hospital GRGlenn A. ReinhartBoehringer Ingelheim (Taiwan)HMH. L. MizelleOrlando Regional Medical Center

Discussion

Member takes

Implication

Renal nerves may facilitate post-ischemic sodium excretion in low-output states; leaves open any role in human HF pending clinical studies.

Key Points

To elucidate whether renal nerves are necessary for promoting renal sodium retention during progressive, chronic reductions in cardiac output.
Surgically divided the urinary bladders of five dogs with unilaterally denervated left kidneys to allow independent 24-hour urine collection from innervated and denervated kidneys (N=5).
Progressively reduced cardiac output using an adjustable pulmonary artery occluder, maintaining right atrial pressure via servo-control at 4.7 ± 0.1, 7.5 ± 0.1, and 9.8 ± 0.2 mmHg for 3 days per level versus baseline (0.9 ± 0.2 mmHg).
At peak right atrial pressure, mean arterial pressure fell by ~25% from 97 ± 3 mmHg, cardiac output fell by ~55% from 2,434 ± 177 ml/min, GFR fell by ~35%, and renal plasma flow fell by ~65%.
No significant differences in renal hemodynamics or sodium excretion occurred between innervated and denervated kidneys during pulmonary artery constriction.
Following occluder release on day 9, 24-hour sodium excretion increased approximately 28% more in innervated kidneys than in denervated kidneys.

Structured PICO

Does renal denervation affect sodium excretion during progressive reductions in cardiac output in a dog model?

Population

5 dogs with surgically divided urinary bladders to allow separate 24-h urine collection from innervated and denervated kidneys

Intervention

Progressive reductions in cardiac output via pulmonary artery constriction (servo-controlling right atrial pressure at 4.7, 7.5, and 9.8 mmHg for 3 days each)

Comparator

Innervated vs denervated kidneys within the same animal

Outcome

Sodium excretion and renal hemodynamics (glomerular filtration rate, renal plasma flow)surrogate

In a canine model of low cardiac output, renal nerves do not significantly promote sodium retention during progressive cardiac output reduction, but they contribute to short-term sodium elimination upon restoration of hemodynamics.

Cite This Study

Lohmeier et al. (1995) studied this question.

synapsesocial.com/papers/6a848874c7e37ebe3168e5a0 https://doi.org/10.1152/ajpregu.1995.269.3.r678

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Implication

Renal nerves may facilitate post-ischemic sodium excretion in low-output states; leaves open any role in human HF pending clinical studies.

Influence of the renal nerves on sodium excretion during progressive reductions in cardiac output

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Influence of the renal nerves on sodium excretion during progressive reductions in cardiac output

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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