Key result
Renal denervation did not alter sodium excretion or renal hemodynamics compared to the innervated kidney during rapid ventricular pacing-induced heart failure in dogs.
Why the study?
Does renal denervation improve sodium excretion in a dog model of pacing-induced chronic congestive heart failure?
Population
10 female dogs with chronic congestive heart failure produced by rapid ventricular pacing
Comparison
Left kidney denervation vs Innervated right kidney in the same dog
Design
Preclinical
Follow-up
6 days of pacing
Authors
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Does not support renal denervation for sodium retention in this pacing-induced HF model; leaves open translation to human disease.
Does renal denervation improve sodium excretion in a dog model of pacing-induced chronic congestive heart failure?
Renal nerves are not primarily responsible for sodium retention in the rapid ventricular pacing dog model of chronic congestive heart failure.
Mizelle et al. (1989) studied Chronic congestive heart failure (n=10). Renal denervation (left kidney) vs. Innervated kidney (same dog) was evaluated on Sodium excretion and renal hemodynamics. Renal denervation did not alter sodium excretion or renal hemodynamics compared to the innervated kidney during rapid ventricular pacing-induced heart failure in dogs.
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