January 1, 1992AJP Regulatory Integrative and Comparative Physiology

Vasopressin responses to unloading arterial baroreceptors during cardiac nerve blockade in conscious dogs

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Population

Conscious dogs

Comparison

Acute cardiac nerve blockade via 2% procaine… vs Pericardial saline infusion with hypotension…

Design

Preclinical

Authors

COC. P. O'DonnellUniversity of California, San Francisco LKL. C. KeilCreighton University TTT. N. ThrasherNational Heart Lung and Blood Institute

Discussion

Member takes

Implication

Arterial baroreceptor unloading appears dominant for AVP release post-CNB in dogs; leaves open human relevance and requires clinical validation.

Structured PICO

Population

Conscious dogs

Intervention

Acute cardiac nerve blockade (CNB) via 2% procaine infusion into the pericardial space, with hypotension induced by thoracic inferior vena caval constriction (TIVCC)

Comparator

Pericardial saline infusion with hypotension induced by TIVCC

Outcome

Plasma arginine vasopressin (AVP) secretionsurrogate

In conscious dogs, the principal stimulus to AVP secretion after acute cardiac nerve blockade arises from unloading the arterial baroreceptors.

Cite This Study

O'Donnell et al. (1992) studied this question.

synapsesocial.com/papers/6a855e0f7fcf0fdb395e1b1b https://doi.org/10.1152/ajpregu.1992.262.1.r51

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Implication

Arterial baroreceptor unloading appears dominant for AVP release post-CNB in dogs; leaves open human relevance and requires clinical validation.

Vasopressin responses to unloading arterial baroreceptors during cardiac nerve blockade in conscious dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vasopressin responses to unloading arterial baroreceptors during cardiac nerve blockade in conscious dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider