Why the study?
Does acute cardiac nerve blockade reduce the increases in plasma AVP, cortisol, and PRA in response to hemorrhage in conscious dogs?
Population
Conscious dogs (n = 9)
Comparison
Acute cardiac nerve blockade produced by… vs Saline infused into the pericardial space
Design
Preclinical
Authors
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Cardiac receptors appear dispensable for hemorrhage responses in dogs; leaves open identification of primary mediators pending higher-species confirmation.
Does acute cardiac nerve blockade reduce the increases in plasma AVP, cortisol, and PRA in response to hemorrhage in conscious dogs?
Input from cardiac receptors is not required for normal AVP, PRA, and cortisol responses to hemorrhage in conscious dogs, suggesting other receptors mediate this response.
O’Donnell et al. (1993) studied this question.
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