June 1, 1987AJP Heart and Circulatory Physiology
Cardiac and arterial baroreceptor influences in release of vasopressin and renin during hemorrhage
Why the study?
What is the role of arterial and cardiac baroreceptors in regulating mean arterial pressure, vasopressin release, and renin activity during hemorrhage in conscious rabbits?
Population
Conscious rabbits
Comparison
Hemorrhage under four conditions: both arterial… vs Within-subject comparison across the four…
Design
Preclinical
Authors
Discussion
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Implication
Animal hemorrhage models should not guide clinical resuscitation; leaves open whether cardiac versus arterial baroreceptors differentially control AVP and MAP in humans.
Structured PICO
What is the role of arterial and cardiac baroreceptors in regulating mean arterial pressure, vasopressin release, and renin activity during hemorrhage in conscious rabbits?
P
Population
Conscious rabbits
I
Intervention
Hemorrhage (bleeding at 2% of blood volume per minute until 35% removed) under four conditions: both arterial and cardiac baroreceptors intact, arterial only intact (cardiac blocked with intrapericardial procaine), cardiac only intact (after sinoaortic denervation), and neither intact
C
Comparator
Within-subject comparison across the four baroreceptor states
O
Outcome
Mean arterial pressure (MAP), arginine vasopressin (AVP) release, and plasma renin activity (PRA)surrogate
In a rabbit hemorrhage model, the hypovolemic stimulus to AVP release is mediated entirely by cardiac baroreceptors, whereas MAP maintenance relies on arterial baroreceptors.
Cite This Study
Quail et al. (1987) studied this question.