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May 1, 1991Circulation ResearchOpen Access

Relative roles of cardiac and arterial baroreceptors in vasopressin regulation during hemorrhage in conscious dogs.

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Population

Conscious splenectomized dogs

Comparison

Hemorrhage with various denervation states vs Hemorrhage with all nerves intact

Design

Preclinical

Authors

YSY. T. ShenDuke UniversityACAllen W. CowleyMedical College of WisconsinSVStephen F. VatnerHeart Failure & Transplant

Discussion

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Implication

Cardiac receptors do not primarily regulate AVP release during hemorrhage in dogs; leaves open their role in human hypovolemia.

Structured PICO

P
Population
Conscious splenectomized dogs
I
Intervention
Hemorrhage (0.5 ml/min/kg) with various denervation states (cardiac denervation, sinoaortic denervation, combined, or ganglionic blockade)
C
Comparator
Hemorrhage with all nerves intact
O
Outcome
Plasma arginine vasopressin (AVP) response to hemorrhagesurrogate

Cardiac receptors are not the primary regulators of AVP release during progressive hemorrhage in conscious dogs, though they play a modest role when sinoaortic reflexes are absent.

Cite This Study

Shen et al. (1991) studied this question.

synapsesocial.com/papers/6a855e0f7fcf0fdb395e1b1chttps://doi.org/10.1161/01.res.68.5.1422
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of afferents from the low-pressure system in the release of antidiuretic hormone during non-hypotensive hemorrhage1968 · 38 citations
  2. 2Role of Cardiovascular Receptors in the Control of ADH Release2008 · 49 citations
  3. 3Reversible blockade of myelinated and non-myelinated cardiac afferents in cats by instillation of procaine into the pericardium1981 · 31 citations
  4. 4Human Splanchnic and Forearm Vasoconstrictor Responses to Reductions of Right Atrial and Aortic Pressures1974 · 341 citations
  5. 5CONTROL OF RELEASE OF VASOPRESSIN BY NEUROENDOCRINE REFLEXES1988 · 165 citations