Why the study?
Does cardiac or ventricular denervation attenuate vasopressin release during hemorrhage in conscious dogs?
Population
Conscious dogs divided into three groups: sham operated, cardiac denervated, and ventricular denervated
Comparison
Cardiac or ventricular denervation vs Sham operation
Design
Preclinical
Authors
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Supports ventricular receptor reflexes as primary mediators of vasopressin release during hemorrhage in dogs; extends mechanistic insights but leaves open human translation.
Does cardiac or ventricular denervation attenuate vasopressin release during hemorrhage in conscious dogs?
This preclinical study demonstrates that a reflex initiated by ventricular receptors is primarily responsible for stimulating vasopressin secretion during hemorrhage in conscious dogs.
Wang et al. (1988) studied this question.
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