Why the study?
Does slow continuous hemorrhage affect renal nerve activity and arterial pressure in conscious dogs with intact or denervated reflexes?
Population
Conscious dogs with all reflexes intact, or after sinoaortic baroreceptor denervation, cardiac denervation…
Comparison
Slow continuous hemorrhage (0.5 ml/kg per min) vs Prehemorrhage control levels and comparison…
Design
Preclinical
Authors
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Should not inform clinical practice; leaves open translation of baroreflex control of renal nerves to human hemorrhage.
Does slow continuous hemorrhage affect renal nerve activity and arterial pressure in conscious dogs with intact or denervated reflexes?
Nonhypotensive hemorrhage in conscious dogs elicits a striking increase in renal nerve activity mediated by sinoaortic and cardiopulmonary baroreceptors, which then declines during hypotensive hemorrhage independent of these reflexes.
Morita et al. (1985) studied this question.
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