Key result
Sustained hemorrhagic hypotension in dogs caused an initial sympathoexcitation mediated by unloading of arterial and cardiopulmonary receptors, followed by vagal afferent-mediated inhibition.
Population
Dogs
Comparison
10 min of sustained hemorrhagic hypotension to a… vs Prebleeding control levels and comparison…
Design
Preclinical
Follow-up
10 minutes
Authors
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Extends animal models of biphasic autonomic response to hemorrhage; leaves open translation to human shock management.
The study demonstrates that the sympathetic response to hemorrhage involves an initial excitation followed by vagal-mediated inhibition that varies by organ.
Koyama et al. (1992) studied Hemorrhagic hypotension. Sustained hemorrhagic hypotension vs. Prebleeding control was evaluated on Sympathetic nerve activities (cardiac, renal, hepatic, adrenal, and splenic). Sustained hemorrhagic hypotension in dogs caused an initial sympathoexcitation mediated by unloading of arterial and cardiopulmonary receptors, followed by vagal afferent-mediated inhibition.
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