December 1, 1971Circulation ResearchOpen Access

Circulatory Reflex from Vagal Afferents in Response to Hemorrhage in the Dog

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Population

35 anesthetized dogs

Comparison

Hemorrhage of 10% of blood volume vs Vagotomy vs intact vagi; carotid baroreflex…

Design

Preclinical

Authors

CPC PelletierHospices Civils de Lyon AEAnthony J. EdisRoyal Adelaide Hospital JSJohn T. ShepherdCross-Cutting Cardiology

Discussion

Member takes

Implication

Animal data implicate vagal cardiopulmonary receptors in hemorrhage compensation; leaves open translation to human shock physiology.

Structured PICO

Population

35 anesthetized dogs

Intervention

Hemorrhage of 10% of blood volume

Comparator

Vagotomy vs intact vagi; carotid baroreflex operative vs held constant

Outcome

Circulatory adjustments (heart rate, constriction of resistance vessels of the hindlimb, renal, and mesenteric beds and of the splanchnic venous bed, and blood pressure)surrogate

Receptors in the cardiopulmonary area, subserved by vagal afferents, exert their main influence on splanchnic resistance and capacitance vessels and renal circulation during hemorrhage.

Cite This Study

Pelletier et al. (1971) studied this question.

synapsesocial.com/papers/6a219367bd959c3a83abe5cd https://doi.org/10.1161/01.res.29.6.626

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Circulatory Reflex from Vagal Afferents in Response to Hemorrhage in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Circulatory Reflex from Vagal Afferents in Response to Hemorrhage in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider