Aortic baroreceptor discharge during nonhypotensive hemorrhage in anesthetized dogs

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Population

Anesthetized dogs (n=3 for nonhypotensive hemorrhage experiments)

Comparison

Slow, continuous hemorrhage until 24 ml blood/kg… vs Cardiac cycles with identical mean aortic…

Design

Preclinical

Authors

Discussion

Challenges nonhypotensive hemorrhage as a selective cardiopulmonary reflex model; hypothesis-generating for baroreflex research in animals.

Population

Anesthetized dogs (n=3 for nonhypotensive hemorrhage experiments)

Intervention

Slow, continuous hemorrhage until 24 ml blood/kg body wt removed

Comparator

Cardiac cycles with identical mean aortic pressures (internal control)

Outcome

Aortic baroreceptor activity (single-unit discharge)surrogate

Nonhypotensive hemorrhage decreases arterial baroreceptor input, challenging its use as a method to selectively study cardiopulmonary reflexes.

Hakumäki et al. (1985) studied this question.

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Challenges nonhypotensive hemorrhage as a selective cardiopulmonary reflex model; hypothesis-generating for baroreflex research in animals.