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November 1, 1967Endocrinology

Role of Peripheral Receptors in the Increased Release of Vasopressin in Response to Hemorrhage

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Why the study?

Does rendering left atrial stretch receptors and carotid sinus baroreceptors inoperative prevent the release of vasopressin in response to hemorrhage in anesthetized dogs?

Population

Anesthetized dogs

Design

Preclinical

Authors

LSLeonard ShareUniversity of Tennessee Health Science Center

Discussion

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Implication

Baroreceptors and vagal afferents are essential for ADH release during hypovolemia in dogs; leaves open translation to human physiology and volume management.

Structured PICO

Does rendering left atrial stretch receptors and carotid sinus baroreceptors inoperative prevent the release of vasopressin in response to hemorrhage in anesthetized dogs?

P
Population
Anesthetized dogs
I
Intervention
Graded, serial hemorrhage with left atrial stretch receptors and carotid sinus baroreceptors rendered inoperative (by cutting the vagi and perfusing the carotid sinuses at constant mean and pulse pressures)
O
Outcome
Plasma titer of ADH (vasopressin)surrogate

This study demonstrates that carotid sinus baroreceptors and vagal afferent receptors are essential for the release of vasopressin in response to hemorrhage.

Cite This Study

Leonard Share (1967) studied this question.

synapsesocial.com/papers/6a855e0e2e6b8eab48d4c64fhttps://doi.org/10.1210/endo-81-5-1140
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of afferents from the low-pressure system in the release of antidiuretic hormone during non-hypotensive hemorrhage1968 · 39 citations
  2. 2Role of the Renin-Angiotensin System in the Vasopressin Response to Hemorrhage1972 · 24 citations
  3. 3Cardiac and arterial baroreceptor influences in release of vasopressin and renin during hemorrhage1987 · 69 citations
  4. 4Relative roles of cardiac and arterial baroreceptors in vasopressin regulation during hemorrhage in conscious dogs.1991 · 40 citations
  5. 5Ventricular receptors stimulate vasopressin release during hemorrhage1988 · 52 citations