Key result
Graded lower body negative pressure increased norepinephrine from 147 to 291 pg/ml (P<0.01) but did not change arginine vasopressin levels, which only increased during marked hypotension.
Why the study?
Does graded lower body negative pressure increase arginine vasopressin and norepinephrine levels in normal humans?
Population
9 individuals without evidence of hypertension or heart disease
Comparison
Graded lower body negative pressure (LBNP) vs Control state (baseline)
Design
Other
Authors
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Differential NE/AVP responses to LBNP in healthy subjects; leaves open relevance to autonomic dysfunction or hypotension in disease.
Does graded lower body negative pressure increase arginine vasopressin and norepinephrine levels in normal humans?
p-value: p=<0.01
Sympathetic activation via cardiopulmonary and sinoaortic baroreceptor unloading during LBNP increases norepinephrine but does not stimulate vasopressin release unless accompanied by hypotension.
Goldsmith et al. (1982) studied Normal humans without hypertension or heart disease (n=9). Graded lower body negative pressure (LBNP) vs. Control state (baseline) was evaluated on Plasma arginine vasopressin (AVP) and norepinephrine (NE) levels (p=<0.01). Graded lower body negative pressure increased norepinephrine from 147 to 291 pg/ml (P<0.01) but did not change arginine vasopressin levels, which only increased during marked hypotension.
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