Key result
Hypertonic saline increases plasma AVP ~82%, but subsequent LBNP produces no further change.
Why the study?
Previous studies showed plasma AVP does not increase with unloading of cardiopulmonary and sinoaortic baroreceptors unless hypotension occurs, but it was unclear if prior osmotic stimulation affects AVP sensitivity to nonosmotic control mechanisms.
Does graded lower body negative pressure alter plasma arginine vasopressin levels after osmotic stimulation in normal humans?
Population
Eight normal individuals in experimental group and five in time control group
Comparison
105-min infusion of 5% saline followed by graded LBNP vs 105-min infusion of 5% saline without LBNP
Design
Physiological study with hypertonic saline infusion and graded LBNP in normal humans
Authors
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Hyperosmolar stimulation does not enhance AVP sensitivity to baroreceptor unloading in normals; leaves open interactions in disease states.
Does graded lower body negative pressure alter plasma arginine vasopressin levels after osmotic stimulation in normal humans?
Osmotic stimulation with hypertonic saline does not unmask a sensitivity of vasopressin release to nonhypotensive baroreceptor unloading in normal humans.
Goldsmith et al. (1985) studied Healthy volunteers (n=13). Lower body negative pressure (LBNP) after hypertonic saline infusion vs. Hypertonic saline infusion without LBNP was evaluated on Change in plasma arginine vasopressin (AVP). Plasma AVP increased from 4.4 to 8.0 pg/ml after 5% saline infusion, but did not change significantly during subsequent lower body negative pressure in normal humans.
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