Why the study?
Does baroreceptor unloading via lower body negative pressure increase plasma arginine vasopressin levels in normal subjects depending on their hydration state?
Population
Normal human subjects in water-replete (n=9) and water-deplete (n=9) states.
Comparison
Lower body negative pressure at -15 mmHg for 30… vs Baseline (control) prior to LBNP.
Authors
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Baroreceptor unloading raises AVP only with elevated osmolality; leaves open clinical relevance for volume regulation in patients.
Does baroreceptor unloading via lower body negative pressure increase plasma arginine vasopressin levels in normal subjects depending on their hydration state?
Physiological unloading of cardiac and arterial baroreceptors significantly increases plasma vasopressin levels in humans only when serum osmolality is elevated, demonstrating an interaction between osmoreceptor and baroreceptor regulation.
Leimbach et al. (1984) studied this question.
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