Key result
Bilateral cervical vagal denervation acutely increased plasma AVP levels by 98 +/- 16 pg/ml at 15 minutes (P<0.01), but levels returned to baseline by 4 hours.
Population
10 conscious dogs with sinoaortic baroreceptor denervation (SAD), as well as dogs with intact reflexes
Comparison
Bilateral cervical vagal denervation and acute… vs Baseline/control values, and dogs with intact…
Design
Preclinical
Follow-up
4 hours
Authors
Loading...
Transient AVP surge after acute vagal denervation in animals; leaves open chronic effects and human cardiovascular relevance.
p-value: p=<0.01
Acute, but not chronic, interruption of vagal pathways induces striking release of AVP, which is rapidly reset to control levels.
Morita et al. (1986) studied Sinoaortic baroreceptor denervation (n=10). Bilateral cervical vagal denervation (VD) vs. Control values (baseline) was evaluated on Plasma arginine vasopressin (AVP) levels (p=<0.01). Bilateral cervical vagal denervation acutely increased plasma AVP levels by 98 +/- 16 pg/ml at 15 minutes (P<0.01), but levels returned to baseline by 4 hours.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: