Vasopressin acts in the area postrema to attenuate the exercise pressor reflex in anesthetized cats

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Population

Anesthetized cats (n=12 total; 9 intact, 3 with sinoaortic denervation)

Comparison

Bilateral microinjections of 200 nl of the AVP… vs Baseline responses before microinjection

Design

Preclinical

Authors

Discussion

Animal data implicate vasopressin in area postrema baroreflex modulation during contraction; leaves open human relevance and therapeutic translation.

Population

Anesthetized cats (n=12 total; 9 intact, 3 with sinoaortic denervation)

Intervention

Bilateral microinjections of 200 nl of the AVP V1-receptor antagonist d(CH2)5Tyr(Me)-AVP (V1x) (1 ng/nl) into the area postrema

Comparator

Baseline responses before microinjection

Outcome

Mean arterial blood pressure and heart rate during 30 s of electrically stimulated hindlimb contractionsurrogate

Arginine vasopressin acts in the area postrema to enhance baroreflex function and attenuate the exercise pressor reflex during static contraction.

Stebbins et al. (1998) studied this question.

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Animal data implicate vasopressin in area postrema baroreflex modulation during contraction; leaves open human relevance and therapeutic translation.