Population
Urethane-anesthetized rats (250-350 g) and Brattleboro rats (genetically deficient in AVP)
Comparison
Arginine vasopressin infusion vs Control (before AVP infusion)
Design
Preclinical
Authors
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No support for peripheral mediation in rats; leaves open central vasopressin sites in baroreflex control.
In a rat model, vasopressinergic augmentation of baroreflex-induced bradycardia does not appear to be mediated by a direct effect on peripheral cardiac parasympathetic innervation.
Pardini et al. (1993) studied this question.
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