Why the study?
Does V2-receptor activation contribute to the augmentation of cardiac baroreceptor reflex sensitivity by arginine vasopressin in conscious rats?
Population
Conscious, chronically instrumented rats (n=15 total across experiments)
Comparison
Arginine vasopressin infusion, V2-antagonist… vs Phenylephrine (PE) or AVP without V2-antagonist
Design
Preclinical
Authors
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V2 contribution to AVP baroreflex augmentation confirmed in conscious rats; leaves open human relevance and therapeutic implications.
Does V2-receptor activation contribute to the augmentation of cardiac baroreceptor reflex sensitivity by arginine vasopressin in conscious rats?
V2-receptor activation contributes to the augmentation of cardiac baroreceptor reflex sensitivity by arginine vasopressin in conscious rats.
Brizzee et al. (1990) studied this question.
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