Population
Male Wistar rats weighing 270-310 g (pithed rat model)
Comparison
Intravenous arginine vasopressin 1 pmol/kg per… vs Absence of AVP during spinal-cord stimulation
Design
Preclinical
Authors
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May unmask AVP facilitation of sympathetic transmission during AT1 blockade; leaves open relevance to human BP control.
In a pithed rat model, vasopressin facilitates sympathetic neurotransmission via presynaptic V1 receptors, an effect masked by endogenous angiotensin II.
Streefkerk et al. (2002) studied this question.