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This research aimed to examine the role of vasopressin in regulating cardiorespiratory responses in hypertensive and normotensive rats.

Vasopressin Contributes to Respiratory and Cardiovascular Regulation in Spontaneously Hypertensive and Normotensive Rats

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Experiment shows vasopressin affects heart rate and respiratory rate in spontaneously hypertensive rats, implying a link with carotid bodies.

This research aimed to examine the role of vasopressin in regulating cardiorespiratory responses in hypertensive and normotensive rats.
Experiments conducted on urethane-anesthetized male spontaneously hypertensive and normotensive Wistar Kyoto rats.
Cardiorespiratory parameters such as blood pressure, heart rate, and ventilation were recorded during vasopressin administration and arterial chemoreflex activation.
Investigated effects of V1a receptor antagonist and carotid body denervation on cardiorespiratory responses.
SHR rats exhibited greater heart rate and respiratory rate compared to normotensive rats.
Intravenous vasopressin significantly increased heart rate in both groups, more in SHR.
CB denervation reduced vasopressin's pressor response and airflow inhibition in SHR, indicating its mediation through carotid bodies.

Proczka et al. (2025) studied this question.

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Experiment shows vasopressin affects heart rate and respiratory rate in spontaneously hypertensive rats, implying a link with carotid bodies.