September 1, 1996AJP Heart and Circulatory Physiology

Central V1 AVP receptors are involved in cardiovascular adaptation to hypovolemia in WKY but not in SHR

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Why the study?

Does central V1 or V2 AVP receptor blockade alter cardiovascular adaptation to hypovolemia in normotensive and spontaneously hypertensive rats?

Population

Conscious normotensive Wistar-Kyoto rats and spontaneously hypertensive rats chronically implanted with…

Comparison

Lateral cerebral ventricle infusion of V1… vs Lateral cerebral ventricle infusion of…

Design

Preclinical

Authors

ABAdam S. BudzikowskiElectrophysiology PPPiotr PaczwaMerck (Germany)ESEwa Szczepańska‐SadowskaMedical University of Warsaw

Discussion

Member takes

Implication

Highlights strain differences in AVP responses to hypovolemia; leaves open clinical relevance of central V1 blockade in humans.

Structured PICO

Does central V1 or V2 AVP receptor blockade alter cardiovascular adaptation to hypovolemia in normotensive and spontaneously hypertensive rats?

Population

Conscious normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) chronically implanted with lateral cerebral ventricle (LCV) cannulas and femoral artery catheters

Intervention

Lateral cerebral ventricle (LCV) infusion of V1 AVP-receptor antagonists {[d(Et2)Tyr(Me)]DAVP, 5 ng/min} or V2 AVP-receptor antagonists {[d(CH2)5-D-Ile2, Ile4, AlaNH2]AVP, 5 ng/min} during arterial bleeding (1.3% body weight)

Comparator

Lateral cerebral ventricle (LCV) infusion of artificial cerebrospinal fluid (control) during arterial bleeding

Outcome

Mean arterial pressure (MAP) and heart rate (HR) responses to arterial bleedingsurrogate

Central V1 AVP receptors mediate hypovolemic bradycardia and hypotension in normotensive rats, but this adaptive mechanism is impaired in spontaneously hypertensive rats.

Cite This Study

Budzikowski et al. (1996) studied this question.

synapsesocial.com/papers/6a8543e7f76e40547ac2b199 https://doi.org/10.1152/ajpheart.1996.271.3.h1057

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Central V1 AVP receptors are involved in cardiovascular adaptation to hypovolemia in WKY but not in SHR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central V1 AVP receptors are involved in cardiovascular adaptation to hypovolemia in WKY but not in SHR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider