What question did this study set out to answer?

To determine the role of arginine-vasopressin compared with the renin-angiotensin system in maintaining elevated blood pressure in stroke-prone spontaneously hypertensive rats.

November 1, 1979Journal of Cardiovascular Pharmacology

Studies on the Role of Vasopressin in Blood Pressure Control of Spontaneously Hypertensive Rats with Established Hypertension (SHR, Stroke-Prone Strain)

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Authors

JMJan MöhringFraunhofer Institute for Industrial Mathematics JKJacqueline KintzUniversity Hospital Bonn JSJosiane SchounUniversity Hospital Bonn

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Implication

Experimental study reveals vasopressin directly maintains blood pressure in stroke-prone hypertensive rats, indicating a dominant role over the renin-angiotensin system.

Key Points

To determine the role of arginine-vasopressin compared with the renin-angiotensin system in maintaining elevated blood pressure in stroke-prone spontaneously hypertensive rats.
Measured plasma arginine-vasopressin (AVP) concentrations in conscious, unrestrained stroke-prone spontaneously hypertensive (SH) rats (aged 22–28 weeks) with benign (BH) or severe-malignant hypertension (S-MH) and normotensive Wistar Kyoto (WKY) controls.
Administered intravenous injections of specific AVP antiserum or saralasin infusions to conscious rats and evaluated hemodynamic responses to exogenous AVP infusion.
Plasma AVP concentrations were elevated twofold in BH rats and fourfold in S-MH rats compared to WKY rats, correlating significantly with blood pressure (r = 0.66, p < 0.001).
Specific AVP antiserum lowered blood pressure by 48 ± 14 mm Hg in BH rats (n=4) and 78 ± 10 mm Hg in S-MH rats (n=4) with only marginal effects in WKY rats (n=4), whereas saralasin lowered pressure in only 2 of 7 S-MH rats (by 15 and 20 mm Hg).
During AVP infusion, SH rats demonstrated a significantly greater blood pressure increase (p < 0.001) and a significantly smaller heart rate reduction (p < 0.001) than WKY rats.

Cite This Study

Möhring et al. (1979) studied this question.

synapsesocial.com/papers/6a714117e5469ee92be1d532 https://doi.org/10.1097/00005344-197911000-00001

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Implication

Experimental study reveals vasopressin directly maintains blood pressure in stroke-prone hypertensive rats, indicating a dominant role over the renin-angiotensin system.

Studies on the Role of Vasopressin in Blood Pressure Control of Spontaneously Hypertensive Rats with Established Hypertension (SHR, Stroke-Prone Strain)

Discussion

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Implication

Key Points

Cite This Study

Studies on the Role of Vasopressin in Blood Pressure Control of Spontaneously Hypertensive Rats with Established Hypertension (SHR, Stroke-Prone Strain)

Discussion

Member takes

Implication

Key Points

Cite This Study

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