Why the study?
Does central dopamine administration reduce blood pressure in hypertensive rat models?
Population
30 rats, comprising 10 spontaneously hypertensive rats, 10 renal artery stenosis hypertensive rats, and 10…
Comparison
Dopamine 0.4 mg/kg injected… vs Baseline blood pressure and intravenous dopamine…
Design
Preclinical
Authors
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Supports central dopaminergic underactivity in SHR hypertension; leaves open relevance to human hypertension.
Does central dopamine administration reduce blood pressure in hypertensive rat models?
Central dopaminergic under-activity may contribute to the pathogenesis of high blood pressure in spontaneously hypertensive rats.
Hutchinson et al. (1984) studied this question.
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