Why the study?
Does antihypertensive therapy with hydralazine and hydrochlorothiazide prevent norepinephrine-induced oscillatory contractions in tail arteries of stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto (WKY) rats
Comparison
Hydralazine and hydrochlorothiazide from weaning… vs Control (untreated) SHRSP and WKY rats
Design
Preclinical
Follow-up
From weaning to 4 months of age
Authors
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Persistent oscillatory activity despite BP reduction in SHRSP; hypothesis-generating for primary vascular abnormality independent of hypertension.
Does antihypertensive therapy with hydralazine and hydrochlorothiazide prevent norepinephrine-induced oscillatory contractions in tail arteries of stroke-prone spontaneously hypertensive rats?
Norepinephrine-induced oscillatory activity in stroke-prone spontaneously hypertensive rats is a primary vascular abnormality that is not secondary to high blood pressure.
Bruner et al. (1987) studied this question.
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