Key result
Spontaneously hypertensive rats show reduced striatal dopamine release alongside ADHD-like behaviors compared to controls.
Why the study?
Earlier work had shown that depletion of brain dopamine can inhibit the age-related rise in blood pressure in spontaneously hypertensive rats, motivating an investigation into the role of central dopamine in the development of hypertension.
Challenges enhanced central dopamine transmission models; hypothesis-generating for striatal dopamine in SHR hypertension and ADHD phenotypes.
We studied the role of central dopamine in the development of hypertension. Earlier work had shown that depletion of brain dopamine can inhibit the age-related rise in blood pressure in spontaneously hypertensive rats (SHR). In an open-field test, locomotor activity of Wistar-Kyoto controls was inhibited by haloperidol, apomorphine and sulpiride, but these drugs had less effect in SHR. The stimulation-evoked release of [3H]-dopamine from slices of the striatum of SHR was smaller than that from slices of WKY. The inhibition of the stimulation-evoked release of [3H]-dopamine by quinpirole was greater in SHR than in WKY. The results from the lesion experiments and from the behavioural activity studies would suggest an enhanced release of central dopamine in SHR, which might contribute to the development of hypertension in these animals. However, the in vitro release experiments (and subsequent in vivo microdialysis experiments) do not support such an enhanced release but rather showed decreased release of striatal dopamine in SHR.
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Buuse et al. (1991) conducted a review in Hypertension and Attention Deficit Hyperactivity Disorder (ADHD) in animal models (Spontaneously Hypertensive Rats and genetic/environmental models). Central dopamine modulation and genetic/environmental ADHD model exposures vs. Wistar-Kyoto (WKY) normotensive controls or wildtype rodents was evaluated on Stimulation-evoked release of [3H]-dopamine and ADHD-like behavioral phenotypes. Spontaneously hypertensive rats exhibit decreased in vitro and in vivo striatal dopamine release compared to Wistar-Kyoto controls, alongside ADHD-like behavioral phenotypes.
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