Why the study?
Does stimulation of left or right atrial receptors affect water intake in response to arterial hypotension in dogs?
Population
Conscious dogs prepared with occluding cuffs on the thoracic inferior vena cava, the pulmonary artery, and…
Comparison
Reduction of mean arterial pressure 25% below… vs Reduction of MAP 25% below control by inferior…
Design
Preclinical
Follow-up
2 hours
Authors
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Left atrial receptor stimulation inhibits drinking during canine hypotension; leaves open translational relevance to human thirst and volume regulation.
Does stimulation of left or right atrial receptors affect water intake in response to arterial hypotension in dogs?
Stimulation of left atrial receptors inhibits drinking in response to arterial hypotension, whereas stimulation of right atrial receptors has no effect in dogs.
Thrasher et al. (1999) studied this question.
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