Why the study?
Does denervation of cardiopulmonary and/or arterial baroreceptors alter long-term blood pressure, heart rate, plasma volume, and plasma renin activity in conscious dogs?
Population
10 conscious, chronically instrumented foxhounds receiving a normal sodium diet
Comparison
Cardiopulmonary denervation, aortic baroreceptor… vs Control group (intact receptors)
Design
Preclinical
Authors
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Isolated baroreceptor function suffices to maintain normal hemodynamics in dogs; leaves open translation to human hypertension or device therapies.
Does denervation of cardiopulmonary and/or arterial baroreceptors alter long-term blood pressure, heart rate, plasma volume, and plasma renin activity in conscious dogs?
The isolated function of either cardiopulmonary or arterial baroreceptors is sufficient to maintain normal blood pressure, heart rate, and plasma renin activity in dogs, with significant increases only seen when both are denervated.
Persson et al. (1987) studied this question.