Key result
Surgical denervation of sinoaortic baroreceptors in conscious dogs resulted in a 33.0 mm Hg fall in mean arterial pressure during coronary occlusion compared to a 9.1 mm Hg fall before denervation.
Why the study?
Does surgical denervation of sinoaortic baroreceptors alter reflex blood pressure control during acute myocardial ischemia in conscious dogs?
Population
Conscious, resting dogs
Comparison
Surgical denervation of sinoaortic baroreceptors… vs The same dogs before denervation undergoing…
Design
Preclinical
Authors
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Sinoaortic denervation worsens ischemia-induced hypotension in dogs; leaves open baroreceptor contributions to perfusion in human acute MI.
Does surgical denervation of sinoaortic baroreceptors alter reflex blood pressure control during acute myocardial ischemia in conscious dogs?
Absolute Event Rate: 33% vs 9.1%
Arterial baroreceptors play a critical role in maintaining perfusion pressure during acute myocardial ischemia by preventing a dilatory response in skeletal muscle and skin vessels.
Peterson et al. (1974) studied Acute Myocardial Ischemia. Surgical denervation of sinoaortic baroreceptors vs. Intact baroreceptors (before denervation) was evaluated on Fall in mean arterial blood pressure during coronary occlusion. Surgical denervation of sinoaortic baroreceptors in conscious dogs resulted in a 33.0 mm Hg fall in mean arterial pressure during coronary occlusion compared to a 9.1 mm Hg fall before denervation.
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