Why the study?
Does alpha- and beta-adrenergic blockade reduce blood pressure and heart rate in conscious foxhounds with chronic sino-aortic and cardiopulmonary denervation?
Population
Conscious foxhounds after chronic sino-aortic and cardiopulmonary denervation (N=6)
Comparison
Administration of prazosin, propranolol, and… vs Baseline
Design
Preclinical
Authors
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Supports enhanced adrenergic control after denervation in dogs; leaves open translation to human baroreflex failure.
Does alpha- and beta-adrenergic blockade reduce blood pressure and heart rate in conscious foxhounds with chronic sino-aortic and cardiopulmonary denervation?
Chronic sino-aortic and cardiopulmonary denervation enhances alpha- and beta-adrenergic components of cardiovascular control, leading to alpha-mediated hypertension and beta-mediated tachycardia.
Persson et al. (1991) studied this question.
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